Studies are conducted in adult male and female Sprague Dawley rats (Envigo) in an AAALAC-accredited facility with approval from an Institutional Animal Care and Use Committee, and implemented in accordance with the Guide for the Care and Use of Laboratory Animals 8th Edition (National Research Council, 2011) with standards set by the National Institutes of Health.

Experimental procedure

Pharmacokinetic (PK) studies are used to guide dosing, select the route of administration, and to determine the levels of the asset over a time course, supporting subsequent behavioral studies.

PK studies are designed based on the asset being evaluated and include evaluation of exposure in both plasma and brain over a time course in male and female rats.


National Research Council (2011). Guide for the Care and Use of Laboratory Animals: Eighth Edition. Washington, DC: The National Academies Press

This work was conducted by PsychoGenics Inc. (Paramus, NJ) in collaboration with PSPP, NINDS, NIH under contract # 75N95019D00026