Preclinical Screening Platform for Pain (PSPP) Database

The NIH HEAL Initiative’s Preclinical Screening Platform for Pain (PSPP) program was developed by the National Institute of Neurological Disorders and Stroke (NINDS) Division of Translational Research to identify and profile non-opioid, non-addictive therapeutics for pain in relevant models including human-based assays.

The PSPP database provides public access to the profiling workflow, testing protocols, and data generated within the program, consistent with the NIH guidelines for rigor and reproducibility. You can visit the Models tab to find descriptions of the models and endpoints used to assess assets in the program. Data generated with clinically used drugs and negative controls can be found by visiting the Database tab, with more data to be added as it is collected.